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NAN® SUPREMEPRO

HUMAN MILK OLIGOSACCHARIDES (HMOS) play a key role in breast milk’s supremacy
Breast milk provides the best nutrition and the best protection, right from the start.1,2 Human milk oligosaccharides (HMOs) are one of breast milk’s most important components. Over 200 HMOs, belonging to 3 families, have been identified so far.3,4 HMOs act as true health guardians. Besides their role in immune health,3,5 emerging research suggests they may also play a role in gut, brain, bone and metabolic health.6-11 

A huge scientific leap was achieved with HMO supplementation of formulas. However, given the wide variety of HMOs in breast milk, an HMO diversity gap still remains between infant formula and breast milk, as HMO blends in formula do not cover the 3 families yet.

NAN® SUPREMEPRO 3
THE FIRST, GROUNDBREAKING INNOVATION TO BRIDGE THE HMO GAP AND SUPPORT LIFELONG IMMUNE HEALTH12-14

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NAN® SUPREMEPRO with 5 HMOs: narrowing the diversity gap between breast milk and infant formula

Backed by over 150 years of infant nutrition expertise, NAN® SUPREMEPRO is the first and only formula supplemented with a unique 5-HMO Complex. The 5 HMOs are among the most abundant HMOs found in breast milk and, together, represent the 3 HMO families. They have been uniquely combined in proportions inspired by those naturally occurring in breast milk. The 5 HMOs may act as true health guardians, helping to build a strong foundation for lifelong immune health.3,5,6-11

 

Supported by the latest research*
 

Latest_Research

NAN® SUPREMEPRO’s components are all clinically proven to support a child’s Immunity, Digestive Health, Metabolism, Growth and Brain Development35-46

OUR INGREDIENTS TO SUPPORT LIFELONG HEALTH:

5-HMO COMPLEX

5-HMO COMPLEX

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GENTLE OPTIPRO®

GENTLE OPTIPRO®

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PROBIOTIC (B. Lactis)

PROBIOTIC (B. Lactis)

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OPTIMIZED LIPID PROFILE WITH DHA

OPTIMIZED LIPID PROFILE WITH DHA

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OUR PRODUCTS

SupremePro1

NAN® SUPREMEPRO 1

Our latest innovation with 5-HMO complex and GENTLE OPTIPRO® for infants 0-6 months.

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SupremePro2

NAN® SUPREMEPRO 2

Our latest innovation with 5-HMO complex and GENTLE OPTIPRO® for older infants from 6-12 months.

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SupremePro3

NAN® SUPREMEPRO 3

Our latest innovation with 5-HMO complex and GENTLE OPTIPRO® for toddlers from 1-3 years old. 

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References:

1. Eidelman AI, Schanler RJ. Pediatrics 2012;129(3):e827-41.
2. Horta B, et al. Long-term effects of breastfeeding: a systematic review, WHO, 2013.
3. Donovan SM, et al. Ann Nutr Metab 2016;69(Suppl 2):42-51.
4. Ninonuevo MR, et al. J Agric Food Chem 2006;54(20):7471-80.
5. Bode L. Glycobiology 2012;22(9):1147–1162.
6. Cho S, et al. Abstract accepted at WCPGHAN Congress 2020.
7. Hauser J, et al. Abstracts 1279 & 1287 accepted at WCPGHAN Congress 2020.
8. Berger B, et al. mBio 2020;11(2):e03196-19.
9. Oliveros E, et al. J Nutr Biochem 2016;31:20-27.
10. Rochat F, et al. Abstract 1431 accepted at WCPGHAN Congress 2020.
11. Bonnet N, et al. Abstract accepted at ASBMR Congress 2020.
12. Nestlé Internal data.
13. Nestlé Internal data.
14. Nestlé Internal data.
15. Reverri E, et al. Nutrients 2018;10(10):1346.
16. Morrow AL, et al. J Pediatr 2004;145(3):297-303.
17. Duska-McEwen G, et al. Food Nutr Sci 2014;5:1387-98.
18. Hester SN, et al. Br J Nutr 2013;110(7):1233-1242.
19. Laucirica DR, et al. J Nutr. 2017;147(9):1709-1714.
20. He S, et al. Gut 2016;65(1):33-46.
21. Kim J, et al l. Infect Immun 2019;87(1):e00694-18.
22. Weichert S, et al. Nutr Res 2013;33(10):831-8.
23. Cravioto A, et al. J Infect Dis 1991;163(6):1247-55.
24. Facinelli B, et al l. J. Matern Fetal Neonatal Med 2019:32(17):2950-2952.
25. Angeloni S, et al. Glycobiology 2005;15:31-41.
26. Lin AE, et al. J Biol Chem 2017;292(27):11243-11249.
27. Alliet P, et al. Abstract accepted 1329 at WCPGHAN Congress 2020.
28. Yu ZT, et al. J Nutr 2016;146(10):1980-90.
29. Allen JM, et al. Front Immunol 2019;10:1774.
30. Goehring KC, et al. J Nutr 2016;146(12):2559-66.
31. Newburg DS, et al. Glycobiology 2004;14(3):253-263.
32. Kang LJ, et al. Br J Pharmacol 2018;175(23):4295-4309.
33. Xiao L, et al. Front Immunol 2018;9:452.
34. Azagra-Boronat I, et al. Front Immunol 2019;10:1773.
35. Exl BM, et al. Eur J Nutr. 2000;39(4):145-56.
36. Storm HM, et al. Glob Pediatr Health. 2019;6:2333794X19833995.
37. Billeaud C, et al. Eur J Clin Nutr. 1990;44(8):577-83.
38. Lewis ZT, et al. Microbiome. 2015;3:13.
39. Zeigler EE, et al. Monatsschr Kinderheilkd. 2003;151(Suppl 1):S65–71.
40. Holscher HD, et al. J Parenter Enteral Nutr. 2012;36(1 Suppl):106S-17S.
41. von Berg A, et al. Allergy. 2016;71(2):210-9.
42. Gappa M, et al. Allergy 2020 Dec 15. doi: 10.1111/all.14709. Online ahead of print.
43. Alexander DD, et al. Am J Clin Nutr. 2016;104(4):1083-1092.
44. Bauer V, et al. Abstract accepted at Pediatric Academic Societies Conference 2021.
45. Birch EE, et al. Dev Med Child Neurol. 2000 Mar;42(3):174-81.
46. Colombo J, et al. Prostaglandins Leukot Essent Fatty Acids. 2017 Jun;121:52-56.
47. 2’FL/DFL: Response letter to GRAS notice GRN000815, August 2019.
48. LNT: Response letter to GRAS notice GRN000833, April 2020.
49. 3’SL: Response letter to GRAS notice GRN000880, April 2020.
50. 6’SL: Response letter to GRAS notice GRN000881, April 2020.
51. EFSA Journal 2019;17(6):5717.
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55. Commission implementing regulation (EU) 2020/484 of 2 April 2020.
56. EFSA Journal 2019;17(12):5907.
57. Triantis V, et al. Front Pediatr. 2018;6:190. Published 2018 Jul 2. 
58. Vandenplas Y, et al. Nutrients. 2018;10(9). pii: E1161. 
59. NAN SupremePRO Labeling Information.
60. Fukushima Y, et al. Bioscience Microflora 1997;6:65-72 
61. Fukushima Y, et al. Int J Food Microbiol 1998;30;42(1-2):39-44
62. Souza CO De, et al. Lipids Health Dis. 2017;16(1).
63. Martin CR, et al. Nutrients. 2016 May 11;8(5). pii: E279.  

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IMPORTANT NOTICE

We believe that breastfeeding is the ideal nutritional start for babies as breast milk provides a balanced diet and protection against illness for a baby. We fully support the World Health Organization’s recommendation of exclusive breastfeeding for the first six months of life followed by the introduction of adequate nutritious complementary foods along with sustained breastfeeding up to two years of age. 
We also recognize that breastfeeding may not be an option due to certain medical conditions. Parents should only feed Infant formula for special medical purposes under supervision of a healthcare professional after full consideration of all feeding options, including breastfeeding. Continued use has to be assessed by the health professional in relation to the baby's progress bearing in mind any social and financial implications for the family. 
Infant formula should always be prepared, used and stored as instructed on the label in order to avoid risks to a baby’s health.